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- Academic Editor
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†These authors contributed equally.
Background: This study explored the specific relationship between
different lipid indicators and cognitive impairment and aimed to provide a
reference for implementing targeted lipid regulation measures to prevent and
alleviate cognitive impairment. Methods: We searched three databases
(PubMed, Embase, and Web of Science) for literature related to hyperlipidaemia,
lipid levels, and cognitive impairment, and used the Newcastle-Ottawa Scale to
evaluate the quality of the identified literature. A meta-analysis was performed
using RevMan 5.4, and the combined effect size ratio using a random-effects model
(odds ratio [OR] and 95% confidence interval [CI]) was used to evaluate the
association between dyslipidaemia and cognitive impairment. Results:
Among initially identified 2247 papers, we ultimately included 18 studies
involving a total of 758,074 patients. The results of the meta-analysis revealed
that patients with hyperlipidaemia had a 1.23-fold higher risk of cognitive
impairment than those with normal lipid levels (OR = 1.23, 95% CI: 1.04–1.47,
p = 0.02). Further subgroup analysis showed that elevated total
cholesterol (TC) levels increased the risk of cognitive impairment by 1.59-fold
(OR = 1.59, 95% CI: 1.27–2.01, p