Staphylococcus aureus and its antibiotic-resistant strains are the cause of soft tissue infections representing some severe life-threatening infections. These situations have caused great concern for its treatment worldwide. Thus, the need to introduce new antibiotics or an alternative to antibiotics markedly increasing. Antimicrobial peptides (AMPs) have been shown to have various properties and uses in the biological system since their discovery. This review is based on the increasing concern for S. aureus, its resistant strains, the associated infections, pathogenicity, and the mechanism of resistance to antibiotics. Lastly, the overall significance of AMPs against S. aureus showed that they can be ideal candidates as an alternative to antibiotics with high potential for future therapeutics.