Background: Coronary artery atherosclerosis development and progression are related to generic, clinical, and lifestyle factors combined with inflammatory activation. The relationship between trace element concentration and morbidity is under investigation to gain a clearer understanding of underlying pathological processes. Methods: Thirty-five consecutive patients (22 males and 13 females) with a median [interquartile range (IQR)] age of 67 (61–73) years presenting with anginal symptoms were included in the single center prospective analysis in 2022 and divided into a epicardial coronary artery disease (CAD) and non-CAD group. Scalp hair chemical analysis and inflammatory markers from a peripheral blood count were analyzed. Results: The correlation analysis of elements and inflammatory indexes showed statistical significance between median hair lithium (Li) concentration and the systemic inflammatory index (SII) (r = –0.476, p = 0.046), antimony (Sb) (r = –0.521, p = 0.028) followed by chromium (Cr) (r = –0.478, p = 0.045) and iron (Fe) (r = –0.604, p = 0.008) in the CAD group. Similar correlations were not found in non-CAD group. Conclusions: The correlation between scalp hair lithium (Li), antimony (Sb), chromium (Cr) and iron (Fe) concentration and the systemic inflammatory index (SII) were revealed only in patients with coronary artery disease. Our analysis identified a strong correlation between inflammatory activation and iron concentration.
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Relation between Systemic Inflammatory Index (SII) and Hair Trace Elements, Metals and Metalloids Concentration in Epicardial Coronary Artery Disease—Preliminary Report
Tomasz Urbanowicz1,*, Anetta Hanć2, Anna Olasińska-Wiśniewska1, Anna Komosa3, Krzysztof J. Filipiak4, Artur Radziemski3, Mateusz Matejuk5, Paweł Uruski3, Andrzej Tykarski3, Marek Jemielity1
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1
Cardiac Surgery and Transplantology Department, Poznan University of Medical Sciences, 61-848 Poznan, Poland
2
Department of Trace Analysis, Faculty of Chemistry, Adam Mickiewicz University, 61-614 Poznan, Poland
3
Department of Hypertensiology, Angiology and Internal Medicine, Poznan University of Medical Sciences, 61-848 Poznan, Poland
4
Institute of Clinical Science, Maria Sklodowska-Curie Medical Academy, 03-411 Warsaw, Poland
5
1st Cardiology Department, Poznan University of Medical Sciences, 61-848 Poznan, Poland
Rev. Cardiovasc. Med. 2023, 24(12), 358;
https://doi.org/10.31083/j.rcm2412358
Submitted: 27 May 2023 | Revised: 24 July 2023 | Accepted: 18 August 2023 | Published: 25 December 2023
(This article belongs to the Section Lifestyle and Risk Factors)
Copyright: © 2023 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.
Abstract
Keywords
lithium
antimony
chromium
iron
SII
atherosclerosis
hair
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