†These authors contributed equally.
Background: This systematic review and meta-analysis aims
to investigate whether antiplatelet agents are associated with the
reduction, expansion, and rupture of abdominal aortic aneurysm (AAA).
Methods: A thorough exploration was conducted on four prominent
databases, namely EMBASE, Ovid, PubMed, and Scopus, to identify studies that
reported the influence of antiplatelet agents on the sac development of AAA. The
assessment was carried out until March 2023. R software v.4.1 was used for
statistical analysis. Results: After reviewing 13 publications which
included a total of 5392 patients (1446 in the antiplatelet group and 2540 in the
control group), a meta-analysis was conducted. The results of the analysis
revealed that there was no significant difference in the annual growth rate of
AAA diameter between those who received antiplatelet agents and those who did not
(mean difference (MD) = –0.04, 95% CI = [–0.37, 0.30]; heterogeneity:
p