†These authors contributed equally.
Background: To explore the effect of granulocyte colony-stimulating
factor (G-CSF) on thin endometrium in women undergoing assisted reproduction.
Methods: We performed a methodical search from their inception to
December 2022 in various electronic databases containing PubMed, Cochrane
Library, Embase, Web of Science, Scopus, in addition to a manual search. All
journals concerning the effect of G-CSF on thin endometrium were found. Selected
studies, collected data, and assessed risk of bias were conducted by two
investigators under precise inclusion and exclusion criteria independently. We
applied Revman 5.3 software to accomplish the Meta-analysis of qualified studies.
Results: This research included 8 studies, including 6 randomized
controlled trials and 2 non-randomized controlled studies, a total of 673
patients. Based on the meta-analysis, we noted that compared with the control
group, G-CSF significant improved embryo implantation rate [risk
ratio (RR) =1.91, 95% confidence interval (CI) (1.26, 2.91), p = 0.002]
and clinical pregnancy rate [RR = 1.73, 95% CI (1.22, 2.45),
p = 0.002]. Compared with the control group, the endometrial thickness
in the G-CSF group had non-significant increase compared with that of the control
group [mean difference (MD) = 0.81, 95% CI (–0.04, 1.67), p = 0.06],
in randomized controlled trial (RCT) studies, subgroup analysis shows G-CSF group
increased significantly [MD = 1.13, 95% CI (0.56, 1.67), p