IMR Press / CEOG / Volume 51 / Issue 4 / DOI: 10.31083/j.ceog5104089
Open Access Review
Progress in Cervical Cancer Biomarkers
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1 Shenzhen University Medical School, Shenzhen University, 518000 Shenzhen, Guangdong, China
2 Department of Clinical Oncology, The University of Hong Kong-Shenzhen Hospital, 518000 Shenzhen, Guangdong, China
*Correspondence: xuzy@hku-szh.org (Zhiyuan Xu)
Clin. Exp. Obstet. Gynecol. 2024, 51(4), 89; https://doi.org/10.31083/j.ceog5104089
Submitted: 16 November 2023 | Revised: 2 January 2024 | Accepted: 10 January 2024 | Published: 3 April 2024
(This article belongs to the Special Issue Cervical Cancer Therapy and Prognosis)
Copyright: © 2024 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.
Abstract

Objective: Cervical cancer (CC) tops the list as the most prevalent malignant tumors of the female reproductive system and is one of the leading causes of cancer-related deaths in women worldwide. To improve the prognosis of CC, research has consistently focus on understanding innovative approaches. Biomarker-guided precision medicine is an important direction to improve prognosis. In this paper, we aim to deepen our understanding of CC biomarkers and accelerate their translation into clinical practice. Mechanism: Literature studies on biomarkers for CC were screened from 23 May 2019 to 23 May 2023. A comprehensive search was performed in NIH/NCBI/PubMed databases. Findings in Brief: There are numerous biomarkers that have a significant role in the diagnosis, prognosis, and treatment of CC. They can influence various processes such as tumour proliferation, invasion, infiltration, and apoptosis. They are also related closely to the sensitivity and resistance of radiotherapy and chemotherapy. Conclusions: To date, multiple CC biomarkers have been identified. Few biomarkers have been successfully applied in clinical practice due to the lack of validation in large-scale clinical studies. Therefore, further clinical studies are necessary to realize the great potential in the clinic.

Keywords
cervical cancer
biomarkers
diagnosis
prognosis
treatment
Funding
JCYJ20210324114600002/Shenzhen Science and Technology Program
JCYJ20230807113009019/Shenzhen Science and Technology Program
SZXK014/Shenzhen Key Medical Discipline Construction Fund
ZDSYS20210623091811035/Shenzhen Key Laboratory for cancer metastasis and personalized therapy
SZSM202211017/Sanming Project of Medicine in Shenzhen
Figures
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